Halyzia®

An advanced iEEG analysis software for epilepsy research

Halyzia® helps you analyze iEEG data and provides objective and easily understandable results.

Halyzia® is currently available for research use.

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Signal brain heart at the end

See Halyzia in action

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POWERFUL SOFTWARE, SEAMLESS NAVIGATION

Navigate easily through your data, even if it lasts for hours or contains a large number of channels.

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multiple recording macro/micro

MICRO/MACRO


Read files from micro, macro or synchronized micro and macro-electrode recordings.

detect biomarker from a signal zoom on a signal

ICTAL AND INTER-ICTAL BIOMARKERS

Detect easily epileptic spikes and high-frequency oscillations (HFOs) such as ripples and fast ripples. Several detectors available. Run seizure analyses using the Epileptogenicity Index.

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INTERACTIVE VISUALIZATION OF RESULTS

Review individual events for confidence, view aggregated events on a topographic brain map.

folder import file EEG data signal

EASY FILE IMPORT


Import your iEEG data, in their original format, including heavy files and signal recorded on micro-electrodes at 32 KHz.

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METRICS EXPORT

Export your metrics in Excel for complementary analyses or research projects.

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SUPPORT

We strive to offer fast, caring, and high-quality support.

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USER-FRIENDLY

Lightweight, no code needed, intuitive interactions with the software.

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STANDALONE OR INTEGRATED

Software that runs as a standalone on your laptop or on a server, or can be integrated to your EEG review software.

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Clinical features

PREPROCESSING

Screenshot of the preprocessing feature

  • View the Power Spectral Density (PSD) of the micro and macro-electrodes to check signal quality.

  • Compare across recordings and patients.

  • Mark electrodes as bad.

  • Zoom in, customize subplots, save figures, and more.

  • Apply a permanent high-pass, low-pass, band-pass and line noise filter to your signal.

ANNOTATIONS AND NOTES

Graph displaying brain wave activity with annotations indicating a spike and fast ripple, with labels 'Spike' and 'Fast ripple', along with a green vertical line marking a cognitive task start.

  • Add annotations with a double left click.

  • Annotate periods and time points easily.

  • Navigate through annotations.

  • Export annotations for easy sharing and analysis.

  • Add notes to highlight specific phases (e.g., sleep, movement).

  • Quickly label and edit your annotations.

  • Move annotations across channels as needed.

  • Work faster with intuitive keyboard shortcuts.

INDIVIDUAL EPILECTIC SPIKES VIEWER

Screenshot of the individual epileptic spikes viewer

  • The epileptic spike event review window allows you to confirm or discard events.

  • Detailed exportable metrics for each detected event, including onset-to-peak amplitude and latency, etc.

  • Multiple signal views to support accurate labelling: raw signal, filtered signal, and superimposed electrode signals.

  • Quick actions via shortcuts and mouse controls.

TOPOGRAPHIC MAP

Screenshot of the topographic map

  • Easily identify the contacts (micro and macro) on which biomarkers of epileptic activity were recorded.

  • Topographic maps for each type of biomarker: epileptic spikes, ripples and fast ripples.

  • Combine events to increase specificity!

  • Label-based filtering for easy navigation.

  • A panel displaying the temporal distribution of detected events throughout the entire recording.

  • Intuitive tools for electrode ordering and naming.

POWERFUL INTUITIVE VIEWER

Screenshot of the powerful intuitive viewer

  • Micro and macro channels displayed simultaneously.

  • Many supported formats: .edf .ncs (Neuralynx) .nsX (1,2,3,4,5,6) .trc (MicroMed), MED, .xls, .csv

  • Intuitive interaction using the mouse, keyboard shortcuts and global navigation bar.

  • Monopolar, bipolar, average and median re-referencing.

  • Easy addition of annotations.

  • Visual indicators of detected biomarkers.

INDIVIDUAL RIPPLES & FAST RIPPLES DETECTOR

Screenshot of the individual ripples and fast ripples detector feature

  • The Fast Ripple and Ripple event review windows allow you to easily label and categorize events by confidence level.

  • Detailed exportable metrics for each detected event, including duration, amplitude, centroid and more.

  • Multiple signal views to support accurate labelling: raw signal, filtered signal, scalogram, and normalized power spectrum.

  • Quick actions via shortcuts and mouse control: zoom, hide filters, and more.

SCALOGRAM ON DEMAND

Screenshot of the scalogram on demand feature

  • Visualize an on-demand scalogram for any selected portion of the signal.

  • Apply filters to refine the signal view.

  • Zoom in or out on the raw signal for detailed inspection.

EPILEPTOGENICITY INDEX

Screenshot of the epileptogenicity index

  • Annotate seizure onsets. 

  • Launch the Epileptogenicity Index tool to analyze the signal based on spectral energy and temporal dynamics.  

  • Visualize resulting Epileptogenicity Index values and rankings across channels. 

Technology behind Halyzia®

Halyzia® integrates WALFRID (Wavelet AnaLysis and IDentification of Fast-Ripples), a new and patented detector, on which Avrio MedTech has exclusive rights.

International patent PCT/EP2022/079304, extended in the US under Patent US 2024/0398319 A1. Detailed information on technology and performance can be found in: Gardy L, Curot J, Valton L, Berthier L, Barbeau EJ, & Hurter C. (2025). Detecting fast-ripples on both micro- and macro-electrodes in epilepsy: A wavelet-based CNN detector. Journal of Neuroscience Methods, 415. https://doi.org/10.1016/j.jneumeth.2024.110350

What our clients and partners say

Christos Lisgaras
NYU Grossman School of Medicine

"The performance of the HFO detector is really good compared with other detectors I have tested. It offers many useful tools that are not available in other software. It is great collaborating with Avrio MedTech, and I look forward to all our future achievements together."

Christos LISGARASResearch Assistant Professor, Department of Psychiatry
New York University Grossman School of Medicine, NY, USA

FHC Inc.

"Integrating Halyzia® into our portfolio represents a significant milestone in our commitment to innovation. Our customers rely on FHC not only for world‑class hardware, but also for powerful, modern analytical software. Halyzia® delivers exactly that, an intuitive, scalable software that elevates the way clinicians and researchers interact with SEEG data."

Cosmin SERBANCEO of FHC, Inc.

Gilles Huberfeld
Hôpital Fondation Adolphe de Rothschild

"Halyzia development was clearly driven by clinicians for smart detection and quantification of spikes and HFOs in intracranial EEG signals."

Dr Gilles HUBERFELDNeurologist, Hôpital Fondation Adolphe de Rothschild, Paris, France

Jonathan Curot
CHU de Toulouse

"Halyzia® truly streamlines the analysis of clinical SEEG data, enabling effortless detection and quantification of HFOs and spikes. I particularly appreciate its user-friendly and intuitive interface, which also offers multiple visualization features—making it an invaluable tool for clinicians and researchers."

Pr Jonathan CUROTNeurologist expert on epilepsy, Toulouse University Hospital
Researcher at the Brain and Cognition Research Center (CerCo, CNRS), Toulouse, France

Marina Inyutina

"Halyzia® is the main tool I use for my work with data from multiple centers. The software is fast and makes data review and interpretation accessible without requiring programming experience. I also provide regular feedback to Avrio MedTech through testing and regular use, and I value their responsiveness and commitment to improving the software based on user input."

Marina INYUTINAResearch engineer at the Brain and Cognition Research Center (CerCo, CNRS), Toulouse, France

"Halyzia® provides an intuitive and powerful entry ramp to powerful and flexible local field potentials (LFP) analysis for users of all skill levels. It is simple enough for novice signal scientists while encompassing the depth required by experienced ones."

Matt STEADFounder of Dark Horse Neuro & co-founder of Neuro Health Collective

Philppe Kahane
Grenoble university hospital

"Halyzia® is an ergonomic solution for analyzing all critical and intercritical SEEG biomarkers. It is an easy‑to‑use software that integrates seamlessly with existing EEG analysis tools, such as those used in Grenoble."

Pr Philippe KAHANENeurologist, Grenoble University Hospital, Grenoble, France

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